In the current machine translation (MT) landscape, the Transformer architecture stands as the gold standard, especially for high-resource language pairs. This research delves into its efficacy for low-resource language pairs including both the English↔Irish and English↔Marathi language pairs. Notably, the study identifies the optimal hyperparameters and subword model type to significantly improve the translation quality of Transformer models for low-resource language pairs. The scarcity of parallel datasets for low-resource languages can hinder MT development. To address this, we developed gaHealth, the first bilingual corpus of health data for the Irish language. Focusing on the health domain, models developed using this in-domain dataset exhibited very significant improvements in BLEU score when compared with models from the LoResMT2021 Shared Task. A subsequent human evaluation using the multidimensional quality metrics error taxonomy showcased the superior performance of the Transformer system in reducing both accuracy and fluency errors compared to an RNN-based counterpart. Furthermore, this thesis introduces adaptNMT and adaptMLLM, two open-source applications streamlined for the development, fine-tuning, and deployment of neural machine translation models. These tools considerably simplify the setup and evaluation process, making MT more accessible to both developers and translators. Notably, adaptNMT, grounded in the OpenNMT ecosystem, promotes eco-friendly natural language processing research by highlighting the environmental footprint of model development. Fine-tuning of MLLMs by adaptMLLM demonstrated advancements in translation performance for two low-resource language pairs: English-Irish and English-Marathi, compared to baselines from the LoResMT2021 Shared Task.