Login (DCU Staff Only)
Login (DCU Staff Only)

DORAS | DCU Research Repository

Explore open access research and scholarly works from DCU

Advanced Search

Translational application of 3D bioprinting for cartilage tissue engineering

McGivern, Sophie, Boutouil, Halima, Al-Kharusi, Ghayadah, Little, Suzanne orcid logoORCID: 0000-0003-3281-3471, Dunne, Nicholas J. orcid logoORCID: 0000-0003-4649-2410 and Levingstone, Tanya J. orcid logoORCID: 0000-0002-9751-2314 (2021) Translational application of 3D bioprinting for cartilage tissue engineering. Bioengineering, 8 (10). ISSN 2306-5354

Abstract
Cartilage is an avascular tissue with extremely limited self-regeneration capabilities. At present, there are no existing treatments that effectively stop the deterioration of cartilage or reverse its effects; current treatments merely relieve its symptoms and surgical intervention is required when the condition aggravates. Thus, cartilage damage remains an ongoing challenge in orthopaedics with an urgent need for improved treatment options. In recent years, major advances have been made in the development of three-dimensional (3D) bioprinted constructs for cartilage repair applications. 3D bioprinting is an evolutionary additive manufacturing technique that enables the precisely controlled deposition of a combination of biomaterials, cells, and bioactive molecules, collectively known as bioink, layer-by-layer to produce constructs that simulate the structure and function of native cartilage tissue. This review provides an insight into the current developments in 3D bioprinting for cartilage tissue engineering. The bioink and construct properties required for successful application in cartilage repair applications are highlighted. Furthermore, the potential for translation of 3D bioprinted constructs to the clinic is discussed. Overall, 3D bioprinting demonstrates great potential as a novel technique for the fabrication of tissue engineered constructs for cartilage regeneration, with distinct advantages over conventional techniques.
Metadata
Item Type:Article (Published)
Refereed:Yes
Uncontrolled Keywords:cartilage; 3D bioprinting; tissue engineering
Subjects:Engineering > Biomedical engineering
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Engineering and Computing > School of Mechanical and Manufacturing Engineering
Research Initiatives and Centres > Advanced Processing Technology Research Centre (APTRC)
Publisher:MDPI
Official URL:https://doi.org/10.3390/bioengineering8100144
Copyright Information:© 2021 The Authors.
Funders:Science Foundation Ireland (SFI) Centre for Research Training in Artificial Intelligence, Grant number 18/CRT/6223, Science Foundation Ireland (SFI) under Grant Number SFI/12/RC/2289_P2, European Regional Development Fund
ID Code:29274
Deposited On:07 Feb 2024 12:10 by Thomas Murtagh . Last Modified 07 Feb 2024 13:49
Documents

Full text available as:

[thumbnail of bioengineering-08-00144-v3.pdf]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Creative Commons: Attribution 4.0
1MB
Downloads

Downloads

Downloads per month over past year

Archive Staff Only: edit this record