The basis of this study is to explore healthcare assistants’ work-related stress while working in palliative care. The study examines palliative care tutors’ and healthcare assistants’ attitudes who work in palliative care in County Roscommon, Ireland. The desired outcome is to explore the possibility of using specific stress reduction techniques to reduce work-related stress for healthcare assistants in the Roscommon area. Therefore, the research focuses on palliative care tutors and healthcare assistants based in Roscommon who have worked, taught, or studied palliative care. This research takes the form of a regional case study based in County Roscommon. Therefore, those participating in the interviews and surveys are all involved in the provision of palliative care education or care staff working directly in palliative care in the Roscommon area. The literature used in this study explores whether stress exists within the palliative care area from the care-worker/healthcare assistant point of view. Also, it examines stress-reduction techniques and their benefits/drawbacks. This is a qualitative study divided into two phases. Phase one focuses on whether stress exists in the career of palliative care assistants. Phase two focuses on whether mindfulness can help deal with palliative care stress. The findings of this study suggest that palliative care is a stressful area for palliative care assistants to work in, and the causes of that stress are multifaceted. Phase two of the study also confirms that for most participant’s palliative care is a stressful area to work in, and for a minority, mindfulness is an effective tool in dealing with that stress.