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The rediscovery of honey for skin Repair: recent advances in mechanisms for honey-mediated wound healing and scaffolded application techniques

Angioi, Roberta orcid logoORCID: 0000-0002-8521-4723, Morrin, Aoife orcid logoORCID: 0000-0002-3031-4794 and White, Blánaid orcid logoORCID: 0000-0003-2982-8752 (2021) The rediscovery of honey for skin Repair: recent advances in mechanisms for honey-mediated wound healing and scaffolded application techniques. Applied Sciences, 11 (11). ISSN 2076-3417

Abstract
Honey is a honey-bee product obtained mainly by the enzymatic processing of nectar from a variety of plants, which leads to the wide range of colours and flavours available on the market. These organoleptic and nutritional features are influenced by the chemical composition, which in turn depends on the botanical origin. Bioactive compounds account for honey beneficial activity in medical applications, which explains the extensive use of honey in ethno-pharmacology since antiquity, from cough remedies to dermatological treatments. Wound healing is one of the main therapeutic uses of honey, and various design options in pharmaceutical technology such as smart delivery systems and advanced dressings are currently being developed to potentiate honey’s valuable properties for better performance and improved final outcome. In this review, we will focus on the latest research that discloses crucial factors in determining what properties are most beneficial when considering honey as a medicinal product. We will present the most recent updates on the possible mechanisms responsible for the exceptional effects of this ageless therapeutical remedy on skin repair. Furthermore, the state-of-the-art in application techniques (incorporation into scaffolds as an alternative to direct administration) used to enhance honey-mediated wound-healing properties are explored.
Metadata
Item Type:Article (Published)
Refereed:Yes
Additional Information:Article number: 5192
Uncontrolled Keywords:honey; antioxidant; antibacterial; anti-inflammatory; polyphenolics; skin; healing; hydrogels
Subjects:UNSPECIFIED
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences
Research Initiatives and Centres > National Centre for Sensor Research (NCSR)
Research Initiatives and Centres > Water Institute
Publisher:MDPI
Official URL:https://dx.doi.org/10.3390/app11115192
Copyright Information:© 2021 The Authors. Open Access (CC-BY 4.0)
Funders:Irish Research Council, Ireland (Government of Ireland Postgraduate Scholarship, GOIPG/2019/4385, R. Angioi).
ID Code:27399
Deposited On:26 Jul 2022 13:46 by Thomas Murtagh . Last Modified 26 Jul 2022 13:46
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