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Calcium phosphate nanoparticles for therapeutic applications in bone regeneration

Levingstone, Tanya J. orcid logoORCID: 0000-0002-9751-2314, Herbaj, Simona and Dunne, Nicholas orcid logoORCID: 0000-0003-4649-2410 (2019) Calcium phosphate nanoparticles for therapeutic applications in bone regeneration. Nanomaterials, 9 (11). ISSN 2079-4991

Abstract
Bone injuries and diseases constitute a burden both socially and economically, as the consequences of a lack of effective treatments affect both the patients’ quality of life and the costs on the health systems. This impended need has led the research community’s efforts to establish efficacious bone tissue engineering solutions. There has been a recent focus on the use of biomaterial-based nanoparticles for the delivery of therapeutic factors. Among the biomaterials being considered to date, calcium phosphates have emerged as one of the most promising materials for bone repair applications due to their osteoconductivity, osteoinductivity and their ability to be resorbed in the body. Calcium phosphate nanoparticles have received particular attention as non-viral vectors for gene therapy, as factors such as plasmid DNAs, microRNAs (miRNA) and silencing RNA (siRNAs) can be easily incorporated on their surface. Calcium phosphate nanoparticles loaded with therapeutic factors have also been delivered to the site of bone injury using scaffolds and hydrogels. This review provides an extensive overview of the current state-of-the-art relating to the design and synthesis of calcium phosphate nanoparticles as carriers for therapeutic factors, the mechanisms of therapeutic factors’ loading and release, and their application in bone tissue engineering.
Metadata
Item Type:Article (Published)
Refereed:Yes
Uncontrolled Keywords:bone tissue engineering; calcium phosphates; drug delivery; gene therapy; nanoparticle; non-viral vectors; therapeutic delivery
Subjects:Engineering > Biomedical engineering
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Engineering and Computing > School of Mechanical and Manufacturing Engineering
Publisher:MDPI
Official URL:https://doi.org/10.3390/nano9111570
Copyright Information:© 2019 The Authors.
ID Code:27284
Deposited On:31 May 2022 15:01 by Thomas Murtagh . Last Modified 07 Feb 2024 13:51
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