This study analyses contemporary cultural representations of HIV/AIDS suffering in the English-speaking global North from screen to celebrity activism and activist campaigns. In doing so, it aims to provide an understanding of whether and how subverting, or queering, cultural discourses around HIV/AIDS suffering can be achieved. In the last couple of years, there has been a change in the way HIV/AIDS is portrayed in popular culture (e.g. Pose, It's a Sin). Rather than offering a nostalgic – and arguably stigmatising – history of the virus, I argue that we have started being presented with mainstream productions which change/queer the way in which HIV/AIDS suffering is represented. We are soon approaching the end of the fourth decade with HIV/AIDS. During the crisis years 1981 – 1996, popular culture treated HIV/AIDS with terror, shame, discrimination, and stigma (Caron, 2001). In 1996, antiretroviral drugs (ARVs) were introduced and rendered life with HIV possible. Since then and until the beginning of the 2010s, the engagement of mainstream culture with HIV/AIDS was significantly minimised (Race, 2001). This silent period came to an end in the 2010s when a renewed interest in HIV/AIDS emerged in popular media and culture (Kagan, 2018). Since the outbreak of the epidemic, numerous academic studies analyse cultural representations of HIV/AIDS arguing that these representations are dictated by heteronormative and homonormative hegemonies aiming at pathologizing non-heterosexual identities (Becker, 2006). My claim is that since 2018 we have been presented with new, queer narratives of HIV/AIDS suffering which reverse the stigmatising discourses that have been associated with the people who live with HIV/AIDS (PLWHA). This investigation provides a queer reading of cultural texts; in particular it focuses on media texts, discussing the ways in which HIV/AIDS suffering is queered in an attempt to de-stigmatise PLWHA.