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“Nano”: an emerging avenue in electrochemical detection of neurotransmitters

Madhurantakam, Sasya, Babu Karnam, Jayanth, Brabazon, Dermot orcid logoORCID: 0000-0003-3214-6381, Takai, Madoka orcid logoORCID: 0000-0002-6238-6717, Ahad, Inam Ul orcid logoORCID: 0000-0002-3802-6156, Balaguru, John Bosco Rayappan orcid logoORCID: 0000-0003-4641-9870 and Maheswari Krishnan, Uma (2020) “Nano”: an emerging avenue in electrochemical detection of neurotransmitters. ACS Chemical Neuroscience, 24 . pp. 4024-4047. ISSN 1948-7193

Abstract
The growing importance of nanomaterials toward the detection of neurotransmitter molecules has been chronicled in this review. Neurotransmitters (NTs) are chemicals that serve as messengers in synaptic transmission and are key players in brain functions. Abnormal levels of NTs are associated with numerous psychotic and neurodegenerative diseases. Therefore, their sensitive and robust detection is of great significance in clinical diagnostics. For more than three decades, electrochemical sensors have made a mark toward clinical detection of NTs. The superiority of these electrochemical sensors lies in their ability to enable sensitive, simple, rapid, and selective determination of analyte molecules while remaining relatively inexpensive. Additionally, these sensors are capable of being integrated in robust, portable, and miniaturized devices to establish point-of-care diagnostic platforms. Nanomaterials have emerged as promising materials with significant implications for electrochemical sensing due to their inherent capability to achieve high surface coverage, superior sensitivity, and rapid response in addition to simple device architecture and miniaturization. Considering the enormous significance of the levels of NTs in biological systems and the advances in sensing ushered in with the integration of nanotechnology in electrochemistry, the analysis of NTs by employing nanomaterials as interface materials in various matrices has emerged as an active area of research. This review explores the advancements made in the field of electrochemical sensors for the sensitive and selective determination of NTs which have been described in the past two decades with a distinctive focus on extremely innovative attribut,es introduced by nanotechnology.
Metadata
Item Type:Article (Published)
Refereed:Yes
Uncontrolled Keywords:Nanomaterials; electrochemistry; biosensors; neurotransmitters; point-of-care; diagnostics
Subjects:Engineering > Materials
Engineering > Mechanical engineering
Engineering > Production engineering
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Engineering and Computing > School of Mechanical and Manufacturing Engineering
Research Initiatives and Centres > Advanced Processing Technology Research Centre (APTRC)
Research Initiatives and Centres > I-Form
Publisher:ACS Publications
Official URL:https://dx.doi.org/10.1021/acschemneuro.0c00355
Copyright Information:© 2020 American Chemical Society
ID Code:26093
Deposited On:09 Aug 2021 15:05 by Dermot Brabazon . Last Modified 26 May 2022 12:17
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