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Endogenous and microbial volatile organic compounds in cutaneous health and disease

Duffy, Emer orcid logoORCID: 0000-0003-4557-6487 and Morrin, Aoife orcid logoORCID: 0000-0002-3031-4794 (2018) Endogenous and microbial volatile organic compounds in cutaneous health and disease. Trends in Analytical Chemistry, 111 . pp. 163-172. ISSN 0165-9936

Abstract
Human skin is a region of high metabolic activity where a rich variety of biomarkers are secreted from the stratum corneum. The skin is a constant source of volatile organic compounds (VOCs) derived from skin glands and resident microbiota. Skin VOCs contain the footprints of cellular activities and thus offer unique insights into the intricate processes of cutaneous physiology. This review examines the growing body of research on skin VOC markers as they relate to skin physiology, whereby variations in skin-intrinsic and microbial metabolic processes give rise to unique volatile profiles. Emerging evidence for volatile biomarkers linked to skin perturbations and skin cancer are examined. Microbial-derived VOCs are also investigated as prospective diagnostic markers, and their potential to shape the composition of the local skin microbiota, and consequently cutaneous health, is considered. Finally, a brief outlook on emerging analytical challenges and opportunities for skin VOC-based research and diagnostics is presented.
Metadata
Item Type:Article (Published)
Refereed:Yes
Uncontrolled Keywords:SkinBiochemistry;Volatile organic compounds; Microbiome; Non-invasive; Metabolism; Skin barrier; Melanoma; Wound healing; Gas chromatography-mass spectrometry
Subjects:Physical Sciences > Analytical chemistry
Physical Sciences > Chemistry
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences
Research Initiatives and Centres > National Centre for Sensor Research (NCSR)
Research Initiatives and Centres > INSIGHT Centre for Data Analytics
Publisher:Elsevier
Official URL:https://doi.org/10.1016/j.trac.2018.12.012
Copyright Information:© 2018 Elsevier
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Horizon 2020 Research and Innovation Fund Marie Sklodowska-Curie Grant 796289, Science Foundation Ireland 13/CDA/2155
ID Code:24873
Deposited On:28 Jul 2020 10:46 by Emer Duffy . Last Modified 25 Jul 2022 17:10
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