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Automation of heterogeneous prostate cancer immunoassay based on multi-valve triggering using purely rotational flow control

Mishra, Rohit orcid logoORCID: 0000-0003-4279-4163, Zapatero-Rodríguez, Julia, Sharma, Shikha, Kelly, Domhnall, McAuley, Darren, O'Kennedy, Richard and Ducrée, Jens orcid logoORCID: 0000-0002-0366-1897 (2016) Automation of heterogeneous prostate cancer immunoassay based on multi-valve triggering using purely rotational flow control. In: The 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 9-13 Oct. 2016, Dublin, Ireland.

Abstract
A multi-marker approach is increasingly considered in diagnosis of prostate cancer to minimize the number of unnecessary biopsies [1]. Centrifugo-pneumatic flow control is often the method of choice for multiplexing such assays [2]. However, the number of assays that can be parallelized on such a dissolvable-film (DF) based system is limited by the substantial spread of the burst frequencies [2] owing to manufacturing tolerances. In this work we substantially enhance the definition of actuation frequencies by 75% using a novel design to enable the automation of multi-step / multi-reagent Lab-on-a-Disc (LoaD) platform. We demonstrate a multi-marker prostate cancer immunoassay panel.
Metadata
Item Type:Conference or Workshop Item (Poster)
Event Type:Conference
Refereed:Yes
Uncontrolled Keywords:Immunoassays; Centrifugal microfluidics; dissolvable film valving; prostate cancer
Subjects:Biological Sciences > Biotechnology
Biological Sciences > Microfluidics
Biological Sciences > Immunology
DCU Faculties and Centres:Research Initiatives and Centres > Biomedical Diagnostics Institute (BDI)
DCU Faculties and Schools > Faculty of Science and Health > School of Physical Sciences
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:European Commission Grant no. 317420, 2012-2016); Science Foundation Ireland (SFI) under Grant No. 10/CE/B1821; SFI-TIDA 13/TIDA/B2692 and SFI-TIDA 14/TIDA/2264.
ID Code:21453
Deposited On:26 Oct 2016 09:52 by Rohit Mishra . Last Modified 27 Aug 2018 09:35
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