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Solvent-selective membranes for automating sequential liquid release and routing of nucleic acid purification protocols on a simple spindle motor

Gaughran, Jennifer orcid logoORCID: 0000-0002-3659-036X, Kinahan, David J. orcid logoORCID: 0000-0003-1968-2016, Mishra, Rohit orcid logoORCID: 0000-0003-4279-4163 and Ducrée, Jens orcid logoORCID: 0000-0002-0366-1897 (2016) Solvent-selective membranes for automating sequential liquid release and routing of nucleic acid purification protocols on a simple spindle motor. In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 9-13 Oct 2016, Dublin, Ireland.

Abstract
By incorporating a set of membranes which selectively dissolve upon contact with aqueous or or-ganic solvents at strategic locations on a disc cartridge, we succeeded to fully automate the solid-phase extraction of nucleic acids by varying the spin rate of a low-cost spindle motor. A solvent- and phase-selective graphene oxide (GO) membrane governs the routing of flows to designated elution and waste chambers. The serial release of on-board sample and reagents is centrifugo-pneumatically controlled by our previously introduced, event-triggered valving scheme. The entire process of ex-traction completes in less than 8 minutes.
Metadata
Item Type:Conference or Workshop Item (Poster)
Event Type:Conference
Refereed:Yes
Uncontrolled Keywords:Graphene oxide membranes; Automation; Nucleic acid purification
Subjects:Engineering > Biomedical engineering
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Physical Sciences
Research Initiatives and Centres > National Centre for Sensor Research (NCSR)
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Programme for Research in Third Level Institutions (PRTLI) Cycle 5, European Regional Development Fund (ERDF)
ID Code:21442
Deposited On:21 Oct 2016 08:08 by David Kinahan . Last Modified 01 Mar 2021 15:21
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