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Disc-embedded grinding mill towards process integtrated hydro-mechanical cell lysis on centrifugal microfluidic platforms

Gaughran, Jennifer orcid logoORCID: 0000-0002-3659-036X, Kelly, Robert, Kinahan, David J. orcid logoORCID: 0000-0003-1968-2016 and Ducrée, Jens orcid logoORCID: 0000-0002-0366-1897 (2016) Disc-embedded grinding mill towards process integtrated hydro-mechanical cell lysis on centrifugal microfluidic platforms. In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 9-13 Oct 2016, Dublin, Ireland. ISBN 978-0-9798064-9-0

Abstract
For the first time we utilize the spindle motor intrinsic to centrifugal microfluidic systems to drive a grinding mill for cell lysis in a stator-rotor concept. This mechanical concept particularly enables the lysis of armored cells and, as a further benefit, avoids the addition of chemicals that potentially inhibit subsequent reactions. As a proof of concept we demonstrate the lysis of the silica-shelled algae Phaeodactylum Tricornutum.
Metadata
Item Type:Conference or Workshop Item (Poster)
Event Type:Conference
Refereed:Yes
Uncontrolled Keywords:Mechanical cell lysis; Centrifugal microfluidics; Stator rotor
Subjects:Engineering > Biomedical engineering
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Physical Sciences
Research Initiatives and Centres > National Centre for Sensor Research (NCSR)
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Programme for Research in Third Level Institutions (PRTLI) Cycle 5. The PRTLI is co-funded through the European Regional Development Fund (ERDF), part of the European Union Structural Funds Programme 2007-2013.
ID Code:21440
Deposited On:20 Oct 2016 10:50 by David Kinahan . Last Modified 01 Mar 2021 15:27
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