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Dynamic pH mapping in microfluidic devices by integrating adaptive coatings based on polyaniline with colorimetric imaging techniques

Florea, Larisa orcid logoORCID: 0000-0002-4704-2393, Fay, Cormac orcid logoORCID: 0000-0001-9104-5527, Lahiff, Emer, Phelan, Thomas, O'Connor, Noel E., Corcoran, Brian, Diamond, Dermot orcid logoORCID: 0000-0003-2944-4839 and Benito-Lopez, Fernando orcid logoORCID: 0000-0003-0699-5507 (2012) Dynamic pH mapping in microfluidic devices by integrating adaptive coatings based on polyaniline with colorimetric imaging techniques. Lab on a Chip, 13 . pp. 1079-1085. ISSN 1473-0197

Abstract
In this paper we present a microfluidic device that has integrated pH optical sensing capabilities based on polyaniline. The optical properties of polyaniline coatings change in response to the pH of the solution that is flushed inside the microchannel offering the possibility of monitoring pH in continuous flow over a 10 wide pH range throughout the entire channel length. This work also features an innovative detection system for spatial localisation of chemical pH gradients along microfluidic channels through the use of a low cost optical device. Specifically, the use of a microfluidic channel coated with polyaniline is shown to respond colorimetrically to pH and that effect is detected by the detection system, even when pH gradients are induced within the channel. This study explores the capability of detecting this gradient by means of imaging techniques and the mapping of the camera’s response to its corresponding pH after a successful calibration process. The provision of an inherently responsive channel means that changes in the pH of a sample moving through the system can be detected dynamically using digital imaging along the entire channel length in real time, without the need to add reagents to the sample. This approach is generic and can be applied to other chemically responsive coatings immobilised on microchannels.
Metadata
Item Type:Article (Published)
Refereed:Yes
Uncontrolled Keywords:optical sensing; polyaniline; pH monitoring
Subjects:Physical Sciences > Chemistry
DCU Faculties and Centres:Research Initiatives and Centres > CLARITY: The Centre for Sensor Web Technologies
Publisher:Royal Society of Chemistry
Official URL:http://dx.doi.org/10.1039/C2LC41065F
Copyright Information:© 2012 RSC
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Irish Research Council (IRC), Science Foundation Ireland under the CLARITY initiative, grant 07/CE/I1147.
ID Code:17680
Deposited On:06 Mar 2013 13:50 by Larisa Florea . Last Modified 19 Sep 2018 14:59
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